If an orange bead is the fourth bead from the clasp, which one of the following is a pair that could be the second an...

From the explanation video, the orange bead is fourth from the clasp: *_ _ _ _. I wanted some explanation on how (E) couldn't work, I thought it could be * R Y P O, because it was explained that (R) could go follow on either side of (PY) if it had a bead. From the explanation video, it seems as though it could work. Please help, thank you!